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Updated: Jul 10, 2026
Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
Published on: August 16, 2015
Estimating the distribution of the G(2) phase duration from flow cytometric histograms
Sara Larsson1, Tobias Ryden, Ulla Holst
1Centre for Mathematical Sciences, Division of Mathematical Statistics, Lund University, 221 00, Lund, Sweden. sara@maths.lth.se
Abstract:
A mathematical model, based on branching processes, is proposed to interpret BrdUrd DNA FCM-derived data. Our main interest is in determining the distribution of the G(2) phase duration. Two different model classes involving different assumptions on the distribution of the G(2) phase duration are considered. Different assumptions of the G(2) phase duration result in very similar distributions of the S phase duration and the estimated means and standard deviations of the G(2) phase duration are all in the same range.
