[Clinical evaluation of enoxacin]

Area of Science:

• Microbiology
• Pharmacology
• Infectious Diseases

Background:

• Enoxacin is a fluoroquinolone antibiotic used for bacterial infections.
• Assessing the efficacy and safety of different enoxacin formulations is crucial for clinical practice.
• Comparative studies with other antibiotics inform treatment guidelines.

Purpose of the Study:

• To evaluate the efficacy and safety of enoxacin tablets and capsules in patients with various infections.
• To compare the effectiveness and tolerability of enoxacin with norfloxacin in treating enteric and urinary tract infections.

Main Methods:

• A total of 436 patients received either enoxacin tablets (336 cases) or capsules (100 cases).
• A randomized controlled trial compared enoxacin with norfloxacin in 209 patients with enteric and urinary infections.

Main Results:

• Enoxacin tablets achieved a 97.0% effective rate and 96.8% bacterial eradication rate.
• Enoxacin capsules demonstrated a 95.0% effective rate and 96.7% bacterial eradication rate.
• Enoxacin showed a comparable effective rate (99.1%) to norfloxacin (95.0%) with a lower incidence of side effects (P < 0.05).

Conclusions:

• Enoxacin, in both tablet and capsule forms, is highly effective and well-tolerated for treating various infections.
• Enoxacin is a safe and effective alternative to norfloxacin for enteric and urinary infections, with a potentially better side effect profile.