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Related Concept Videos

Gastrulation01:56

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

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Related Experiment Video

Updated: Jul 10, 2026

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations
08:35

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations

Published on: February 12, 2010

Photoactivatable GFP resolves Drosophila mesoderm migration behaviour.

Michael J Murray1, Robert Saint

  • 1The ARC Special Research Centre for the Molecular Genetics of Development and Molecular Genetics and Evolution Group, Research School of Biological Sciences, The Australian National University, Canberra, ACT 2601, Australia.

Development (Cambridge, England)
|October 19, 2007
PubMed
Summary
This summary is machine-generated.

Mesoderm cell migration in Drosophila embryos was visualized using photoactivatable-GFP. Inner cells move dorsolaterally, driven by chemotaxis and differential affinity, revealing key mechanisms in embryonic development.

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Last Updated: Jul 10, 2026

Live Imaging Of Drosophila melanogaster Embryonic Hemocyte Migrations
08:35

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Published on: February 12, 2010

Live Imaging of Glial Cell Migration in the Drosophila Eye Imaginal Disc
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Published on: July 9, 2009

Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages
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Imaging and Analysis of Tissue Orientation and Growth Dynamics in the Developing Drosophila Epithelia During Pupal Stages

Published on: June 2, 2020

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Mesoderm migration is crucial for embryonic development.
  • Drosophila gastrulation provides a model for studying mesoderm spreading.
  • Previous studies lacked visualization of mesodermal cell behavior in vivo.

Purpose of the Study:

  • To visualize and characterize mesodermal cell migration during Drosophila gastrulation.
  • To elucidate the mechanisms driving mesodermal cell spreading.
  • To understand the role of specific cell behaviors in embryonic development.

Main Methods:

  • Utilized photoactivatable-GFP fused to alpha-Tubulin (PAGFP-Tub) for live imaging.
  • Employed laser-photoactivation of specific mesodermal cell populations.
  • Observed cell migration patterns in relation to ectodermal cells.

Main Results:

  • Outer mesodermal cells migrate dorsolaterally as a group.
  • Inner mesodermal cells migrate dorsolaterally away from the midline.
  • Cells at the furrow center disperse and intercalate with outer cells.
  • Movement is dependent on the FGF receptor Heartless.

Conclusions:

  • Chemotactic movement and differential cell affinity are primary drivers of mesoderm spreading.
  • Detailed characterization of cell behaviors provides insights into gene function.
  • This study enhances understanding of early mesoderm development mechanisms.