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Biochemical Purification and Proteomic Characterization of Amyloid Fibril Cores from the Brain
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Linking folding with aggregation in Alzheimer's beta-amyloid peptides

Jana Khandogin1, Charles L Brooks

  • 1Department of Molecular Biology,Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 19, 2007
PubMed
Summary

Alzheimer's beta-amyloid (Abeta) peptides aggregate more readily in acidic endosomal environments. This suggests Abeta oligomers may form inside cells before contributing to disease pathology.

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