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Updated: Jul 10, 2026
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Improved Method for the Preparation of a Human Cell-based, Contact Model of the Blood-Brain Barrier
Published on: November 12, 2013
The endothelium, platelets, and brain ischemia.
1Department of Neurology, Harvard Medical School, Boston, MA, USA.
Reviews in Neurological Diseases
|October 19, 2007
Summary
Antithrombotic treatments target blood clots in cerebrovascular disease. Strategies include affecting platelets, endothelium, and fibrinogen levels for various clinical needs.
Area of Science:
- Cardiovascular Medicine
- Neurology
- Hematology
Background:
- Occlusive cerebrovascular disease, brain ischemia, and infarction involve blood platelets and thrombi.
- Understanding thrombus formation is crucial for developing antithrombotic treatments.
Purpose of the Study:
- To outline the rationale and strategies for antithrombotic treatment in cerebrovascular diseases.
- To discuss the varying clinical situations requiring antithrombotic interventions.
Main Methods:
- Review of current antithrombotic treatment strategies.
- Categorization of treatments based on their mechanism of action on platelet-fibrin clot formation.
- Discussion of agent classes: platelet/endothelium modifiers, glycoprotein IIb/IIIa inhibitors, and fibrinogen level reducers.
Main Results:
- Four general strategies exist for reducing white platelet-fibrin clots.
- Specific agents mentioned include dipyridamole, cilostazol, and glycoprotein IIb/IIIa inhibitors.
- Treatment selection depends on clinical context, such as stent placement or penetrating artery disease.
Conclusions:
- Antithrombotic treatment is essential for managing occlusive cerebrovascular disease.
- Tailoring treatment based on affected pathways (platelets, endothelium) and clinical scenario is key.
- Further research may refine agent selection for optimal patient outcomes.
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