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Bacterial pathogenomics.

Mark J Pallen1, Brendan W Wren

  • 1Centre for Systems Biology, University of Birmingham, Birmingham B15 2TT, UK. m.pallen@bham.ac.uk

Nature
|October 19, 2007
PubMed
Summary

Sequencing bacterial genomes reveals surprising evolutionary forces. Horizontal gene transfer and genome decay significantly impact pathogen evolution, prompting re-evaluation of pathogen and virulence factor definitions.

Area of Science:

  • Microbiology
  • Genomics
  • Evolutionary Biology

Background:

  • Numerous bacterial genomes, including pathogens and commensals, have been sequenced.
  • Genomic analysis offers insights into microbial evolution and biology.

Purpose of the Study:

  • To analyze sequenced bacterial genomes to understand pathogen evolution.
  • To identify key forces driving the evolution of bacterial pathogens.
  • To re-evaluate current definitions of 'pathogen' and 'virulence factor'.

Main Methods:

  • Comparative genomic analysis of sequenced bacterial genomes.
  • Bioinformatic approaches to identify evolutionary patterns and genetic mechanisms.

Main Results:

  • Genomic sequencing has illuminated unexpected aspects of pathogen biology.

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  • Horizontal gene transfer and genome decay were identified as crucial in bacterial pathogen evolution.
  • The study challenges traditional definitions of pathogens and virulence factors.

    • Conclusions:

    • Bacterial genome sequencing provides critical insights into evolutionary processes.
    • Evolutionary mechanisms like horizontal gene transfer and genome decay are fundamental to understanding pathogenicity.
    • Revisiting the definitions of pathogen and virulence factor is necessary based on genomic evidence.