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Related Experiment Video

Updated: Jul 10, 2026

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Rapid Mix Preparation of Bioinspired Nanoscale Hydroxyapatite for Biomedical Applications

Published on: February 23, 2017

Dissolution of human teeth-derived hydroxyapatite.

Dong Seok Seo¹, Jong Kook Lee

¹BK21 Education Center of Mould Technology for Advanced Materials & Parts, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju, 501-759, Republic of Korea.

Annals of Biomedical Engineering

|October 19, 2007

Summary

Biologically derived hydroxyapatite (BHA) from human teeth shows superior stability compared to artificial hydroxyapatite (HA). BHA exhibits less dissolution in water, indicating its potential for durable applications.

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Area of Science:

Biomaterials Science
Ceramics Engineering
Dental Materials

Background:

Human teeth are primarily composed of hydroxyapatite (HA), known for their long-term stability.
Man-made hydroxyapatite (HA) materials often suffer from dissolution and mechanical degradation.
Developing more stable HA-based biomaterials is crucial for various applications.

Purpose of the Study:

To prepare biologically derived hydroxyapatite (BHA) ceramics from human teeth.
To investigate the dissolution behavior of BHA in distilled water and compare it with artificial HA.
To evaluate the stability and degradation mechanisms of BHA.

Main Methods:

Human teeth were calcined at 900°C and sintered at 1200°C to create BHA ceramics.
BHA and artificial HA were immersed in distilled water for 3-14 days.
Material characterization using X-ray diffraction (XRD) and surface analysis to observe dissolution patterns.

Main Results:

Artificial HA showed surface dissolution at grain boundaries, leading to pore formation.
BHA consisted of a mixture of HA and beta-tricalcium phosphate (TCP).
Beta-TCP phases in BHA predominantly dissolved, while the HA matrix remained stable, indicating robust grain boundaries.

Conclusions:

Biologically derived hydroxyapatite (BHA) from human teeth demonstrates enhanced stability in aqueous environments compared to artificial HA.
The dissolution of BHA is primarily attributed to the beta-TCP phase, leaving the HA matrix intact.
BHA exhibits promising properties for applications requiring long-term stability and resistance to degradation.