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Related Experiment Video

Updated: Jul 10, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
07:50

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

Published on: December 8, 2023

Two new lanostanoids from Ganoderma resinaceum.

Xue-Mei Niu1, Sheng-Hong Li, Wei-Lie Xiao

  • 1School of Chinese Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China.

Journal of Asian Natural Products Research
|October 19, 2007
PubMed
Summary
This summary is machine-generated.

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Two new lanostane triterpenoids were isolated from Ganoderma resinaceum. One compound demonstrated significant cytotoxic activity against the Hep-2 cell line.

Area of Science:

  • Natural Products Chemistry
  • Pharmacognosy
  • Organic Chemistry

Background:

  • Ganoderma species are a rich source of bioactive compounds.
  • Triterpenoids, particularly lanostanes, are known for diverse pharmacological properties.
  • Investigating novel compounds from medicinal mushrooms like Ganoderma resinaceum is crucial for drug discovery.

Purpose of the Study:

  • To isolate and characterize novel lanostane triterpenoids from Ganoderma resinaceum.
  • To evaluate the cytotoxic potential of the isolated compounds.
  • To contribute to the understanding of the chemical diversity and bioactivity of Ganoderma species.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structure elucidation employing extensive spectroscopic methods, particularly Nuclear Magnetic Resonance (NMR) spectroscopy.

Related Experiment Videos

Last Updated: Jul 10, 2026

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum
07:50

2D-HPLC-MS Technology Combined with Molecular Network for the Identification of Components in Tibetan Medicine Aconitum pendulum

Published on: December 8, 2023

  • Cytotoxicity assessment using the Hep-2 cell line and determining the half-maximal inhibitory concentration (IC50).

    • Main Results:

    • Two new lanostane triterpenoids, 3-epipachymic acid and a derivative of pachymic acid, were identified.
    • A known compound, 3-oxo-5alpha-lanosta-8,24-dien-21-oic acid, was also isolated.
    • Compound 2 exhibited significant cytotoxic activity against Hep-2 cells with an IC50 value of 2.5 microg/ml.

    Conclusions:

    • The study successfully identified novel lanostane triterpenoids from Ganoderma resinaceum.
    • Compound 2 displays promising cytotoxic effects, warranting further investigation for potential therapeutic applications.
    • This research expands the knowledge of bioactive metabolites from Ganoderma species.