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Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Related Experiment Video

Updated: Jul 10, 2026

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Corneal Epithelial Abrasion with Ocular Burr As a Model for Cornea Wound Healing

Published on: July 10, 2018

Interventions for recurrent corneal erosions.

S L Watson¹, N H Barker

¹Department of Ophthalmology, Corneal and External Diseases, Prince of Wales Hospital, Randwick, Australia, NSW 2031. s.watson@unsw.edu.au

The Cochrane Database of Systematic Reviews

|October 19, 2007

Summary

Limited evidence suggests oral tetracycline or excimer laser may treat recurrent corneal erosion. However, more high-quality trials are needed to confirm the effectiveness and safety of various treatments and prophylactic regimens for this condition.

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Area of Science:

Ophthalmology
Corneal Diseases
Evidence-Based Medicine

Background:

Recurrent corneal erosion (RCE) causes significant ocular discomfort and increases infection risk.
It often follows corneal trauma, and preventive measures are not well-established.
Current treatments may fail, leading to persistent symptoms or further episodes, with no consensus on optimal management.

Purpose of the Study:

To evaluate the efficacy and safety of different prophylactic and treatment strategies for recurrent corneal erosion.

Main Methods:

Searched multiple databases (CENTRAL, MEDLINE, EMBASE, LILACS) and contacted researchers.
Included randomized and quasi-randomized trials comparing interventions for RCE.
Independently extracted data and assessed trial quality, contacting authors for missing information.

Main Results:

Five randomized and one quasi-randomized trial were included, noted for heterogeneity and poor quality.
Limited evidence suggests oral tetracycline or excimer laser may be effective treatments for RCE.
Therapeutic contact lens wear was less effective than lubricants and had higher complication rates; prophylactic ointments showed no significant differences.

Conclusions:

High-quality, masked, randomized controlled trials with standardized methods are essential.
Further research is needed to establish definitive benefits of existing and novel prophylactic and treatment regimens for RCE.