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Related Experiment Video

Updated: Jul 10, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Medical interventions for primary open angle glaucoma and ocular hypertension.

C Vass¹, C Hirn, T Sycha

¹Vienna Medical University, Department of Ophthalmology, Währinger Gürtel 18-20, Wien, Austria, A-1090. clemens.vass@meduniwien.ac.at

The Cochrane Database of Systematic Reviews

|October 19, 2007

Summary

Topical pharmacological treatments effectively lower intraocular pressure (IOP) and prevent visual field (VF) defects in ocular hypertension (OHT). Beta-blockers show some benefit, but treatment decisions remain individualized.

Related Experiment Videos

Last Updated: Jul 10, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

Area of Science:

Ophthalmology
Pharmacology
Clinical Trials

Background:

Primary open-angle glaucoma (POAG) is a progressive optic neuropathy characterized by elevated intraocular pressure (IOP), optic nerve damage, and visual field (VF) loss.
Ocular hypertension (OHT) presents with elevated IOP but without optic nerve or VF pathology, yet it is a significant risk factor for POAG development.

Purpose of the Study:

To evaluate and compare the efficacy of topical pharmacological treatments in preventing the onset or progression of glaucomatous optic neuropathy in patients with POAG or OHT.

Main Methods:

A systematic review and meta-analysis of randomized controlled trials (RCTs) were conducted.
Searches included CENTRAL, MEDLINE, and EMBASE databases, supplemented by bibliographical reviews and expert consultations.
Data from 26 RCTs involving 4979 participants were analyzed, focusing on treatment duration of at least one year.

Main Results:

Meta-analysis of 10 trials demonstrated a significant reduction in the onset of VF defects in treated OHT patients (OR 0.62).
No single drug class showed statistically significant VF protection compared to placebo or untreated controls.
Weak evidence suggested a potential VF protective effect for beta-blockers (OR 0.67).

Conclusions:

Medical IOP-lowering treatment demonstrates a clear visual field protective effect in OHT.
While beta-blockers show some promise, direct comparisons for newer agents like prostaglandins or brimonidine against placebo are lacking.
Treatment decisions should be individualized based on patient-specific factors such as IOP level, existing damage, and age.