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Updated: Jul 10, 2026
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
Directly observed therapy for treating tuberculosis.
1Stellenbosch University, Faculty of Health Sciences, PO Box 19063, Tygerberg, Cape Town, South Africa, 7505. jvolmink@sun.ac.za
The Cochrane Database of Systematic Reviews
|October 19, 2007
Summary
Directly Observed Therapy (DOT) for tuberculosis treatment showed no significant difference in cure rates compared to self-administration. Home-based DOT may offer a slight advantage, but overall, DOT does not appear to quantitatively improve tuberculosis treatment outcomes.
Area of Science:
- Public Health
- Infectious Diseases
- Clinical Trials
Background:
- Policies promoting adherence to tuberculosis treatment regimens are crucial.
- Directly Observed Therapy (DOT) is a strategy where healthcare providers or others observe patients ingesting antituberculous medications.
Purpose of the Study:
- To evaluate the effectiveness of DOT compared to self-administration or alternative DOT strategies for tuberculosis treatment and prevention.
Main Methods:
- A systematic review and meta-analysis of randomized and quasi-randomized controlled trials were conducted.
- Searches included major databases (Cochrane, MEDLINE, EMBASE, LILACS) and trial registries.
- Data were extracted and analyzed using relative risks and confidence intervals, with a fixed-effect model.
Main Results:
- Eleven trials involving 5609 participants were analyzed.
- No statistically significant difference in cure rates was found between DOT and self-administration.
- Home-based DOT showed a potential small advantage for cure compared to clinic-based DOT.
Conclusions:
- Randomized controlled trials do not provide evidence that DOT significantly improves tuberculosis cure or treatment completion rates compared to self-administration.
- The findings apply to low-, middle-, and high-income countries.
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