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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Peripheral Artery Disease I: Introduction01:30

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Computerized Dynamic Posturography for Postural Control Assessment in Patients with Intermittent Claudication
14:52

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Published on: December 11, 2013

Omega-3 fatty acids for intermittent claudication.

T Sommerfield1, J Price, W R Hiatt

  • 1NHS National Services Scotland, Information and Statistics Division, 1st Floor, Area 113D, Gyle Square, 1 South Gyle Crescent, Edinburgh, UK, EH12 9EB. tsommerfield@nhs.net

The Cochrane Database of Systematic Reviews
|October 19, 2007
PubMed
Summary

Omega-3 fatty acid supplementation showed no significant clinical benefits for intermittent claudication. While some haematological effects were noted, increased LDL cholesterol and gastrointestinal issues were observed, warranting further research.

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Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Pharmacology

Background:

  • Omega-3 fatty acids are recognized for their efficacy in managing coronary artery disease.
  • Similarities in pathogenesis suggest potential benefits for peripheral arterial disease, including intermittent claudication.

Purpose of the Study:

  • To evaluate the clinical and hematological impacts of omega-3 supplementation in individuals experiencing intermittent claudication.

Main Methods:

  • Systematic review of randomized controlled trials comparing omega-3 fatty acids with placebo or other interventions.
  • Searches included major databases and literature from nutritional organizations and pharmaceutical companies.

Main Results:

  • Six studies with 313 participants were analyzed; no significant improvements were found in ankle brachial pressure index, walking distances, or blood pressure.
  • A decrease in blood viscosity was observed, alongside gastrointestinal side effects.
  • Omega-3 supplementation led to increased levels of total and LDL cholesterol.

Conclusions:

  • Omega-3 fatty acids offer limited hematological benefits for intermittent claudication and do not consistently improve primary clinical outcomes.
  • Potential adverse effects include elevated cholesterol levels, necessitating further investigation into short- and long-term clinical outcomes.