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Nutrient-enriched formula versus standard term formula for preterm infants following hospital discharge

G Henderson, T Fahey, W McGuire

    The Cochrane Database of Systematic Reviews
    |October 19, 2007
    PubMed

    Insights

    Feeding preterm infants nutrient-enriched formula after hospital discharge did not significantly improve growth or development. Some studies showed lower weights and lengths at six months, with no long-term differences observed up to 18 months.

    Area of Science:

    • Neonatal nutrition
    • Pediatric development
    • Growth monitoring

    Background:

    • Preterm infants often experience growth restriction post-hospital discharge.
    • Nutrient-enriched formulas may promote catch-up growth and enhance development in these infants.

    Purpose of the Study:

    • To evaluate the impact of nutrient-enriched formula versus standard term formula on the growth and development of preterm infants after hospital discharge.

    Main Methods:

    • Systematic review and meta-analysis of randomized controlled trials.
    • Searches conducted across multiple databases including CENTRAL, MEDLINE, EMBASE, and CINAHL.
    • Data extraction and quality assessment performed by two independent reviewers.

    Main Results:

    • Seven trials involving 631 infants were included, generally of good quality.
    • Limited evidence suggests nutrient-enriched formula does not significantly affect growth or development.
    • Some trials indicated lower weights, lengths, and head circumferences at six months post-term with enriched formulas, but no significant differences at 12-18 months.

    Conclusions:

    • Current data do not strongly support the use of nutrient-enriched formula for improving growth or development in preterm infants up to 18 months post-term.
    • Further research is needed to assess long-term outcomes in later childhood.
    Abstract

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