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Nutrient-enriched formula milk versus human breast milk for preterm infants following hospital discharge

G Henderson, T Fahey, W McGuire

    The Cochrane Database of Systematic Reviews
    |October 19, 2007
    PubMed

    Insights

    No studies compared nutrient-enriched formula versus breast milk for preterm infant growth post-discharge. More research is needed to determine optimal feeding strategies for catch-up growth in preterm infants.

    Area of Science:

    • Neonatal nutrition
    • Pediatric development
    • Growth studies

    Background:

    • Preterm infants often experience growth restriction upon hospital discharge.
    • Nutrient-enriched formula may promote catch-up growth and improve development compared to human breast milk after discharge.

    Purpose of the Study:

    • To evaluate the impact of nutrient-enriched formula versus human breast milk on the growth and development of preterm infants after hospital discharge.

    Main Methods:

    • A systematic literature search was conducted using standard Cochrane Neonatal Review Group strategies.
    • Included were randomized or quasi-randomized controlled trials comparing nutrient-enriched formula with human breast milk for preterm infants post-discharge.
    • Trial quality and data extraction were performed by two independent reviewers.

    Main Results:

    • No eligible randomized controlled trials were identified in the search.

    Conclusions:

    • Currently, no randomized controlled trial data exist to compare nutrient-enriched formula with human breast milk for preterm infant growth and development post-discharge.
    • Mothers and healthcare providers need strong evidence of benefits before substituting nutrient-enriched formula for breast milk.
    • Future trials comparing nutrient-enriched versus standard formula could inform the design of studies investigating nutrient-enriched formula against breast milk.
    Abstract

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