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Updated: Jul 10, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Topical pimecrolimus for eczema.

D M Ashcroft¹, L-C Chen, R Garside

¹University of Manchester, School of Pharmacy and Pharmaceutical Sciences, 1st Floor, Stopford Building, Oxford Road, Manchester, UK, M13 9PT. Darren.ashcroft@manchester.ac.uk

The Cochrane Database of Systematic Reviews

|October 19, 2007

Summary

Topical pimecrolimus is less effective than corticosteroids for eczema treatment and has uncertain therapeutic value. Further research is needed to clarify its role in managing atopic dermatitis.

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Last Updated: Jul 10, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Area of Science:

Dermatology
Pharmacology
Clinical Trials

Background:

Pimecrolimus offers an alternative to topical corticosteroids for eczema (atopic dermatitis).
Its comparative efficacy and safety against existing treatments require clarification.

Purpose of the Study:

To assess the effects of topical pimecrolimus in treating eczema.
Evaluate efficacy, tolerability, and safety compared to other treatments.

Main Methods:

Systematic review of randomized controlled trials (RCTs) up to October 2006.
Included 31 RCTs with 8019 participants comparing 1.0% topical pimecrolimus with comparators.
Data analyzed using a random-effects model for pooled risk ratios and confidence intervals.

Main Results:

Pimecrolimus was more effective and better tolerated than vehicle in short-term use.
Long-term use showed pimecrolimus superior to vehicle in preventing flares and improving quality of life.
Pimecrolimus was less effective than triamcinolone acetonide and betamethasone valerate, with more withdrawals and burning; less effective than tacrolimus.

Conclusions:

Topical pimecrolimus demonstrates lower efficacy compared to moderate/potent corticosteroids and 0.1% tacrolimus.
Its therapeutic role in eczema management remains uncertain due to a lack of comparison with mild corticosteroids.