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Related Experiment Videos

Steroids for traumatic optic neuropathy.

P Yu-Wai-Man1, P G Griffiths

  • 1Royal Victoria Infirmary, Department of Ophthalmology, Newcastle upon Tyne, UK, NE1 4LP. patrick.yu-wai-man@ncl.ac.uk

The Cochrane Database of Systematic Reviews
|October 19, 2007
PubMed
Summary
This summary is machine-generated.

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Steroids do not appear to improve vision in traumatic optic neuropathy (TON). Current evidence suggests steroids may even be harmful, especially when treatment is delayed beyond eight hours post-injury.

Area of Science:

  • Ophthalmology
  • Neurology
  • Trauma Care

Background:

  • Traumatic optic neuropathy (TON) causes severe vision loss after head trauma.
  • Optic nerve swelling can lead to secondary retinal ganglion cell loss.
  • Steroids and surgical decompression are considered for improving visual prognosis in TON.

Purpose of the Study:

  • To review the effectiveness and safety of steroid use in traumatic optic neuropathy.

Main Methods:

  • Searched multiple databases (Cochrane, MEDLINE, EMBASE, LILACS) and reference lists for randomized controlled trials (RCTs).
  • Included RCTs comparing steroid regimens (alone or with surgery) to surgery alone or no treatment.
  • Two authors independently assessed study titles and abstracts.

Related Experiment Videos

Main Results:

  • No studies met the selection criteria for inclusion in the analysis.
  • No randomized controlled trials were identified.

Conclusions:

  • No convincing data supports steroid benefit in TON; spontaneous recovery is common.
  • Recent evidence suggests potential detrimental effects of steroids in TON.
  • Steroid treatment is not recommended for TON cases presenting >8 hours post-injury; earlier treatment decisions are controversial and require individual assessment.