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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jul 10, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

Immunizations for children with cancer.

Upton D Allen1

  • 1Division of Infectious Diseases, Department of Paediatrics, Hospital for Sick Children, University of Toronto, Ontario, Canada. upton.allen@sickkids.ca

Pediatric Blood & Cancer
|October 19, 2007
PubMed
Summary

Children with cancer face risks from infections. This review outlines key principles for safely and effectively vaccinating these vulnerable children, addressing data gaps.

Area of Science:

  • Pediatric Oncology
  • Immunology
  • Infectious Diseases

Background:

  • Children with malignant diseases are highly susceptible to severe outcomes from vaccine-preventable infections.
  • Vaccinating immunocompromised children presents unique challenges regarding vaccine efficacy and safety.
  • Current vaccination guidelines often rely on data from healthy populations and expert consensus due to limited specific research.

Purpose of the Study:

  • To review the principles of vaccine use in pediatric cancer patients.
  • To provide a framework for guiding vaccination decisions in children with malignant diseases.
  • To address the paucity of data on vaccinating this specific population.

Main Methods:

  • Literature review focusing on vaccine use in pediatric oncology.

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Last Updated: Jul 10, 2026

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation
15:04

Potentiation of Anticancer Antibody Efficacy by Antineoplastic Drugs: Detection of Antibody-drug Synergism Using the Combination Index Equation

Published on: January 19, 2019

  • Synthesis of existing data and expert opinion on vaccine efficacy and safety in immunocompromised children.
  • Identification of key principles for vaccination strategies.

    • Main Results:

    • Vaccination is crucial for protecting children with cancer against preventable infections.
    • Specific considerations regarding vaccine types, timing, and safety monitoring are necessary.
    • A framework is proposed to guide clinical decision-making for vaccine administration.

    Conclusions:

    • Vaccination is a vital component of supportive care for children undergoing cancer treatment.
    • Tailored vaccination strategies are essential to maximize protection while minimizing risks.
    • Further research is needed to optimize vaccine protocols for pediatric cancer patients.