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Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Mucosal Barrier of the Stomach01:25

Mucosal Barrier of the Stomach

The gastric glands contain parietal cells that secrete hydrochloric acid (HCl) for digestion. The cells secrete HCl because it is highly corrosive and essential for breaking down food. To achieve this, they secrete hydrogen and chloride ions into the lumen of the gastric glands, which combine to form HCl.
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Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents01:24

Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents

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Bone Marrow Sampling and Transplants

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Related Experiment Video

Updated: Jul 10, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model

Published on: August 29, 2012

Mucosal graft-vs-host disease.

J Lew1, J A Smith

  • 1Laboratory of Immunology, National Eye Institute, Bethesda, MD, USA.

Oral Diseases
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Graft-vs-host disease (GVHD) is a significant complication following hematopoietic stem cell transplantation (HSCT). This review updates understanding of GVHD, focusing on its mucosal manifestations in light of evolving transplant practices and therapies.

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Last Updated: Jul 10, 2026

Induction of Graft-versus-host Disease and In Vivo T Cell Monitoring Using an MHC-matched Murine Model
10:29

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07:59

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Published on: January 2, 2017

Area of Science:

  • Hematology
  • Immunology
  • Transplantation Medicine

Background:

  • Graft-vs-host disease (GVHD) is a major complication after hematopoietic stem cell transplantation (HSCT).
  • The expansion of HSCT indications and improved immunosuppressive strategies have altered GVHD's incidence and presentation.
  • Mucosal GVHD is a frequent and often debilitating manifestation.

Purpose of the Study:

  • To provide an updated review of Graft-vs-host disease (GVHD).
  • To highlight the evolving landscape of GVHD in hematopoietic stem cell transplantation (HSCT).
  • To specifically emphasize the mucosal manifestations of GVHD.

Main Methods:

  • Comprehensive review of current scientific literature.
  • Analysis of recent trends in HSCT indications and immunosuppressive therapies.
  • Synthesis of data focusing on GVHD, particularly mucosal involvement.

Main Results:

  • Hematopoietic stem cell transplantation (HSCT) is increasingly utilized for a wider range of conditions.
  • Immunosuppressive therapies for GVHD prevention and treatment have advanced.
  • The evolving treatment landscape impacts GVHD presentation, including mucosal sites.

Conclusions:

  • GVHD remains a critical challenge in HSCT.
  • Understanding current GVHD trends, especially mucosal manifestations, is crucial for patient care.
  • Ongoing research and clinical practice updates are necessary to manage GVHD effectively.