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Updated: Jul 10, 2026

An In Vitro Model for Studying Cellular Transformation by Kaposi Sarcoma Herpesvirus
Published on: August 25, 2017
HIV-associated Kaposi sarcoma: pathogenesis and therapy
Anja Potthoff1, Norbert H Brockmeyer
1Department of Dermatology and Allergy, St. Josef Hospital, Ruhr-University Bochum, Germany.
Abstract:
While classical Kaposi sarcoma is a slowly progressing tumor, AIDS-related Kaposi sarcoma is much more aggressive. After introduction of antiretroviral therapy and with the use of well- tolerated chemotherapeutic agents, complete remission of the tumor can be achieved. Local therapeutic options include excision, cryosurgery, radiation and alitretinoin gel. In 45 % of patients with more than 400/microl CD4+ lymphocytes, interferon-alpha induces complete remission. New concepts of pathogenesis lead to therapeutic targets, such as inhibition of angiogenesis.
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