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Updated: Jul 10, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

Published on: February 28, 2012

Atrial fibrillation and stroke prevention.

Gregory Y H Lip¹, Hoong Sern Lim

¹University Department of Medicine, City Hospital, Birmingham, UK. g.y.h.lip@bham.ac.uk

The Lancet. Neurology

|October 20, 2007

Summary

Anticoagulant therapy effectively prevents stroke in atrial fibrillation (AF) patients, especially the elderly. However, this stroke prevention treatment is underused due to concerns about bleeding risks and uncertain thromboembolism risk assessment.

Area of Science:

Cardiology
Neurology
Pharmacology

Background:

Atrial fibrillation (AF) is a prevalent arrhythmia linked to significant stroke and thromboembolism risk.
Anticoagulant therapy is proven to reduce stroke risk, with greatest benefit in high-risk individuals.
Despite proven benefits, anticoagulant use, particularly in the elderly, remains suboptimal.

Purpose of the Study:

To review evidence supporting and opposing warfarin and aspirin for stroke prevention in AF.
To discuss clinical assessments and risk stratification for guiding antithrombotic therapy in AF patients.
To explore barriers hindering the adoption of anticoagulation therapy for stroke prevention.

Main Methods:

Literature review of studies on warfarin and aspirin for stroke prevention in AF.

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Analysis of clinical trial data regarding benefits and risks of anticoagulation.

Discussion of risk stratification tools and clinical guidelines.

Main Results:

Anticoagulant therapy significantly reduces stroke risk in AF patients.
Aspirin offers less effective stroke prevention compared to anticoagulants.
Underuse of anticoagulation may stem from perceived risks and uncertain individual risk assessment.

Conclusions:

Anticoagulant therapy is crucial for stroke prevention in AF, particularly for the elderly.
Addressing barriers to anticoagulation uptake is essential for improving patient outcomes.
Risk-benefit assessment and patient selection are key to optimizing antithrombotic therapy.