Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Sexually Dimorphic Responses Reveal Multifaceted Benefits of Glibenclamide in Traumatic Brain Injury.

Journal of neurotrauma·2025

Same author

Intra-Arterial Deoxyribonuclease Therapy Improves Stroke Outcomes in Aged Mice.

CNS neuroscience & therapeutics·2025

Same author

A novel early onset spinocerebellar ataxia 13 BAC mouse model with cerebellar atrophy, tremor, and ataxic gait.

Experimental animals·2025

Same author

SCUBA evacuation within 24 hours of basal ganglia hemorrhage results in promising functional outcomes.

Journal of neurointerventional surgery·2025

Same author

Robot-Assisted Transcranial Doppler Versus Transthoracic Echocardiography for Right to Left Shunt Detection.

Stroke·2023

Same author

Editorial: Cerebrovascular disease.

Current opinion in neurology·2023

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Stroke vs. status epilepticus. A case report utilizing CT perfusion.

Vladimir Royter¹, Laurie Paletz, Michael F Waters

¹Cedars-Sinai Medical Center, Los Angeles, CA, USA. vladimir.royter@cshs.org

Journal of the Neurological Sciences

|October 20, 2007

Summary

Differentiating strokes from seizures can be difficult. This case highlights how CT-perfusion and EEG confirmed status epilepticus (epileptic seizures) in a patient initially evaluated for ischemic stroke.

More Related Videos

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Related Experiment Videos

Last Updated: Jul 10, 2026

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Optimized System for Cerebral Perfusion Monitoring in the Rat Stroke Model of Intraluminal Middle Cerebral Artery Occlusion

Published on: February 17, 2013

Area of Science:

Neurology
Neuroimaging
Neurophysiology

Background:

Distinguishing between acute ischemic stroke and seizures is clinically challenging due to overlapping symptoms.
Prompt and accurate diagnosis is crucial for appropriate treatment and patient outcomes.

Observation:

A patient presented with symptoms concerning for acute ischemic stroke.
Initial clinical presentation mimicked cerebrovascular events.

Findings:

Computed tomography (CT) perfusion imaging was utilized to assess blood flow in the brain.
Electroencephalography (EEG) confirmed the presence of non-convulsive status epilepticus.
The diagnostic workup successfully differentiated between stroke and seizure activity.

Implications:

This case underscores the importance of advanced neuroimaging and electrophysiological studies in complex neurological presentations.
Utilizing CT-perfusion and EEG can aid in the accurate diagnosis of status epilepticus, even when stroke is suspected.
Improved diagnostic strategies can lead to timely and targeted therapeutic interventions for seizure disorders.