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Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

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Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

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Wet Beveling of Microinjection Needles Utilizing Constant Air Pressure for Feedback on Needle Opening

Wet Beveling of Microinjection Needles Utilizing Constant Air Pressure for Feedback on Needle Opening

Published on: September 27, 2024

A Lorentz-force actuated autoloading needle-free injector.

Brian D Hemond¹, Dawn M Wendell, N Cathy Hogan

¹Mechanical Engineering Dept., Massachusetts Institute of Technology, Cambridge, MA 02139, USA. bhemond@mit.edu

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference

|October 20, 2007

Summary

This study introduces a novel needle-free injector with precise control over injection depth and pressure. The device utilizes a Lorentz-force actuator for accurate drug delivery, overcoming limitations of conventional needle-free systems.

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Microinjectrode System for Combined Drug Infusion and Electrophysiology

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Published on: November 13, 2019

Area of Science:

Biomedical Engineering
Drug Delivery Systems
Medical Devices

Background:

Needle-free injection methods offer advantages over traditional needles.
Existing needle-free technologies often lack precise control over injection depth and delivery patterns.

Purpose of the Study:

To design, construct, and test a novel needle-free injector.
To achieve precise control over injection parameters like depth and pressure.

Main Methods:

Development of a needle-free injector utilizing a controllable linear Lorentz-force actuator.
Testing the device for repeatability and evaluating depth control accuracy.
Utilizing acrylamide gel and dye for experimental validation.

Main Results:

The Lorentz-force actuator enabled rapid control of injection pressure.
The designed injector demonstrated precise control over delivery parameters.
Experimental evaluation confirmed the device's repeatability and depth control capabilities.

Conclusions:

The developed needle-free injector offers superior control over injection depth and pressure.
This technology addresses limitations in conventional needle-free injection systems.
The device shows potential for accurate and controlled drug delivery applications.