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Spiral Ganglion Neuron Explant Culture and Electrophysiology on Multi Electrode Arrays
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A microsystem with varying-length electrode arrays for auditory nerve prostheses.

Jian Wu1, Weifeng Feng, W C Tang

  • 1Electr. Eng. & Comput. Sci. Dept., California Univ., Irvine, CA 92697, USA. jianw@uci.edu

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary

Researchers developed a novel micromachined electrode array for auditory nerve prostheses, enabling broader neural stimulation. An ultra-low power circuit was also created for neural signal recording, enhancing cochlear implant technology.

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Electrical Engineering

Background:

  • Auditory nerve prostheses aim to restore hearing by stimulating remaining auditory nerve fibers.
  • Current prostheses face challenges in accessing diverse nerve fascicles for broad tonotopic stimulation.
  • Efficient, low-power electronics are crucial for implantable neural devices.

Purpose of the Study:

  • To design, fabricate, and simulate a novel micromachined electrode array with varying lengths for auditory nerve prostheses.
  • To develop and test a multichannel, ultra-low power integrated circuit for neural signal recording.
  • To improve the potential for broad tonotopic stimulation within the auditory nerve.

Main Methods:

  • Fabrication of a 10x10 electrode array on silicon using bulk micromachining technology.
  • Varying electrode lengths from 200 to 400 micrometers to target different nerve fascicles.
  • Design and fabrication of a multichannel ultra-low power circuit using 0.5 microm AMI CMOS technology.

Main Results:

  • Successful design and simulation of a novel micromachined electrode array with variable lengths.
  • Fabrication of a 1mm² electrode array on silicon.
  • Development of a 1.5mm x 1.5mm integrated circuit with total power consumption under 100 microwatts.

Conclusions:

  • The novel electrode array design offers potential for accessing most auditory nerve fascicles.
  • This design facilitates stimulation across a broad tonotopic range within the nerve fiber.
  • The developed ultra-low power circuit is suitable for neural signal recording in implantable devices.