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Updated: Jul 10, 2026
08:34
Cryogenic Liquid Jets for High Repetition Rate Discovery Science
Published on: May 9, 2020
The effect of jet parameters on jet injection
Dawn M Wendell1, Brian D Hemond, N Cathy Hogan
1Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dawn@mit.edu
Summary
Understanding jet injection parameters is crucial. This study shows that a high initial pressure followed by sustained lower pressure is key for successful needle-free injections in animal tissues.
Area of Science:
- Biomedical Engineering
- Drug Delivery Systems
- Tissue Mechanics
Background:
- Current jet injection devices rely on fixed impulse mechanisms (compressed air/springs).
- Limited understanding of how injection parameters influence efficacy and tissue interaction.
- Invariable injection profiles hinder optimization and parameter exploration.
Purpose of the Study:
- To investigate the impact of injection parameters on jet injection into biological tissues.
- To elucidate the role of the fluid ejection profile in jet injection performance.
- To establish optimal pressure profiles for effective needle-free drug delivery.
Main Methods:
- Utilized a controllable jet injection device for precise parameter manipulation.
- Conducted experiments on ex vivo sheep and pig tissue models.
- Analyzed the effects of varying injection pressure profiles on tissue penetration and fluid distribution.
Main Results:
- Demonstrated that an initial peak in injection pressure is critical for successful skin penetration.
- Identified a subsequent lower, sustained follow-through pressure as essential for complete delivery.
- Highlighted the significant influence of the pressure profile on injection outcomes in animal tissues.
Conclusions:
- Successful jet injection necessitates a dynamic pressure profile, not a single impulse.
- Optimizing the initial peak and follow-through pressure enhances needle-free injection efficacy.
- Findings provide a foundation for designing next-generation controllable jet injection devices.
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