Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Correlated Discretized Expression score: a method for identifying gene interaction networks from time course

Peter Larsen1, Eyad Almasri, Guanrao Chen

  • 1Core Genomics Lab., Illinois Univ., Chicago, IL 60607-7058, USA. plarsen@uic.edu

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fully Automated Production of Multiple <sup>11</sup>C-Labeled PET Tracers Using a Self-Cleaning TracerMaker Radiosynthesizer.

Journal of labelled compounds & radiopharmaceuticals·2026
Same author

Response to: 'Re: impact of digital versus faxed e-referrals on triage decisions in a medical retina clinic'.

Clinical & experimental optometry·2026
Same author

"It Feels Like Another Thing Cancer Took From Me"- Exploring Cervical Cancer Patients' Experience of Financial Toxicity in Aotearoa, New Zealand.

Journal of medical imaging and radiation oncology·2026
Same author

Femoral neck fracture increases 30-day mortality 16-fold and elevates mortality risk for up to 4 years: a matched cohort study of 3,246 patients.

European geriatric medicine·2026
Same author

Impact of digital versus faxed e-referrals on triage decisions in a medical retina clinic.

Clinical & experimental optometry·2026
Same author

Measurement properties of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for patella fractures.

Injury·2026
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

This study introduces a new method using Correlated Discretized Expression (CDE) scores to identify gene interaction networks from time course microarray data, revealing causal relationships in gene regulation.

Area of Science:

  • Genomics
  • Systems Biology
  • Bioinformatics

Background:

  • Gene interaction network construction is crucial for understanding cellular processes.
  • Time course microarray data offers insights into dynamic gene regulation.
  • Identifying causal relationships between regulators and targets remains challenging.

Purpose of the Study:

  • To develop a novel system for identifying gene regulatory patterns from time course microarray data.
  • To propose a method for constructing gene interaction networks by analyzing temporal expression changes.
  • To assess the effectiveness of the proposed system in uncovering gene expression dynamics.

Main Methods:

  • The study utilizes Correlated Discretized Expression (CDE) scores.
  • Microarray data is discretized to highlight significant gene expression changes.

Related Experiment Videos

  • Biological expectations of regulatory interactions inform pattern identification.

    • Main Results:

    • The Correlated Discretized Expression (CDE) score effectively identifies significant gene expression changes.
    • The proposed system successfully demonstrates the identification of gene expression patterns.
    • Analysis of hypothetical and S. cerevisiae cell cycle data validates the method's utility.

    Conclusions:

    • The Correlated Discretized Expression (CDE) score provides a robust method for analyzing time course microarray data.
    • This approach facilitates the construction of gene interaction networks and the understanding of regulatory dynamics.
    • The system is effective for both simulated and real biological datasets, including the S. cerevisiae cell cycle.