Sensitivity of rheoencephalographic measurements to spatial brain electrical conductivity

Rheoencephalography (REG) is impedance plethysmography applied to the head, and provides an indirect measurement of the pulsatility of the cerebral blood volume. To extend REG as a clinical and research tool, it is necessary to evaluate the sensitivity of REG measurement to local brain conductivity changes. By means of the analytical solution of a four-sphere geometrical model of the head, maps of impedance sensitivity were assessed for different electrode arrangements. Results showed a selective distribution of sensitivities, with a preference for cortical areas under electrodes. This suggests a potential for application of REG to regional evaluation of cortical cerebral perfusion.