Related Experiment Video
Updated: Jul 10, 2026
08:50
Longitudinal Morphological and Physiological Monitoring of Three-dimensional Tumor Spheroids Using Optical Coherence Tomography
Published on: February 9, 2019
Advances in contrast enhancement for optical coherence tomography
1Dept. of Electrical & Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. boppart@uiuc.edu
Summary
Optical coherence tomography (OCT) contrast is often limited. This study explores novel methods, including exogenous agents and endogenous molecular sampling, to enhance OCT imaging for better tissue identification.
Area of Science:
- Biomedical Optics
- Medical Imaging
- Ophthalmology
Background:
- Optical coherence tomography (OCT) provides high-resolution cross-sectional imaging.
- Limited contrast in OCT hinders differentiation between normal and pathological tissues.
- Developing enhanced OCT contrast methods is crucial for accurate diagnosis.
Purpose of the Study:
- To discuss novel methods for enhancing OCT contrast.
- To enable selective identification of specific tissues using OCT.
- To explore both exogenous and endogenous contrast-enhancing techniques.
Main Methods:
- Administration of passive or targeted exogenous contrast agents.
- Utilizing linear and nonlinear optical techniques.
- Sampling endogenous molecular composition of tissues.
Main Results:
- Exogenous agents can be multifunctional, aiding therapy and localization.
- Novel methods aim to improve selectivity in tissue identification.
- Exploitation of endogenous signals offers an alternative contrast enhancement strategy.
Conclusions:
- Advanced OCT contrast enhancement techniques are vital for improved medical imaging.
- Multifunctional contrast agents offer dual diagnostic and therapeutic potential.
- Novel methods promise enhanced visualization and identification of target tissues.
Related Concept Videos
01:10Computed Tomography
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
01:27Imaging Studies III: Computed Tomography
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
01:26Phase Contrast and Differential Interference Contrast Microscopy
Phase-Contrast Microscopes
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
In-phase-contrast microscopes, interference between light directly passing through a cell and light refracted by cellular components is used to create high-contrast, high-resolution images without staining. It is the oldest and simplest type of microscope that creates an image by altering the wavelengths of light rays passing through the specimen. Altered wavelength paths are created using an annular stop in the condenser. The annular stop produces a hollow cone of...
01:18Imaging Biological Samples with Optical Microscopy
Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
01:28Imaging Studies for Cardiovascular System V: CT
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
01:14Imaging Studies I: CT and MRI
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...