Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Subthalamic nucleus deep brain stimulation: accurate axonal threshold prediction with diffusion tensor based electric

Ashutosh Chaturvedi1, Christopher R Butson, Scott E Cooper

  • 1Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Motor evoked potentials as markers of internal capsule current spread during deep brain stimulation for Parkinson's disease.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

Localizing beta synchronous neurons in the STN using directional DBS recordings and patient-specific biophysical models.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2026
Same author

A novel methodology for localizing pallidal deep brain stimulation leads.

Frontiers in neuroanatomy·2026
Same author

Optimal Deep Brain Stimulation Locations for Gilles de la Tourette Syndrome.

medRxiv : the preprint server for health sciences·2026
Same author

Model-based design of subthalamic nucleus neurons using hybrid optimization.

Journal of neurophysiology·2026
Same author

Nanoscale symmetry protection of the reciprocal acoustoelectric effect.

Scientific reports·2026

Accurate modeling of deep brain stimulation (DBS) for Parkinson's Disease requires complex computational approaches. Simplified models overestimate neural activation, highlighting the need for detailed simulations in subthalamic nucleus (STN) DBS research.

Area of Science:

  • Neuroscience
  • Computational Biology
  • Biomedical Engineering

Background:

  • Deep brain stimulation (DBS) is a primary treatment for medically intractable Parkinson's Disease.
  • The precise mechanisms underlying DBS therapeutic effects and neural tissue interactions are not fully understood.
  • Accurate computational models are crucial for understanding DBS and optimizing treatment.

Observation:

  • This study developed computational models of subthalamic nucleus (STN) DBS with increasing complexity.
  • Models incorporated electrode-tissue interface capacitance, encapsulation, and anisotropic tissue properties.
  • Model predictions were validated against clinical corticospinal tract (CST) activation thresholds in a patient.

Findings:

  • Highly detailed computational models, including tissue anisotropy and electrode properties, accurately predicted axonal activation thresholds.

More Related Videos

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

Related Experiment Videos

Last Updated: Jul 10, 2026

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

  • Simpler, commonly used neurostimulation models significantly overestimated neural activation.
  • The most complex model, incorporating capacitance, encapsulation, and anisotropy, was necessary for accurate CST threshold prediction.

    • Implications:

    • Sophisticated computational modeling is essential for understanding DBS mechanisms and patient-specific responses.
    • Overestimation by simplified models can lead to inaccurate predictions of DBS efficacy and side effects.
    • These findings advance the development of more precise and effective DBS therapies for Parkinson's Disease.