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Updated: Jul 10, 2026

Transmembrane Domain Oligomerization Propensity determined by ToxR Assay
Published on: May 26, 2011
Linear discrimination of transmembrane from non-transmembrane segments in proteins using higher-order crossings
Ilias K Kitsas1, Stavros M Panas, Leontios J Hadjileontiadis
1Dept. of Electr. & Comput. Eng., Aristotle Univ. of Thessaloniki, Thessaloniki, Greece. ikitsas@auth.gr
Abstract:
Identification of transmembrane segments in protein sequences is an important issue in the field of bioinformatics. In this study, a method is proposed for linear discrimination between transmembrane and non-transmembrane segments, combining chemical and statistical features of the proteins with higher-order crossings analysis for protein segment classification. The method was tested on human proteins extracted from public available databases and the results have shown a remarkable efficiency of the proposed algorithm to correctly classify the sequence segments under study into two linearly separated classes, for a wide range of transmembrane segment lengths.
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