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Cardiac arrhythmogenesis and temperature.

Ujas Shah1, Harold Bien, Emilia Entcheva

  • 1Biomedical Engineering Department, Stony Brook University, Stony Brook, NY 11794, USA. uhshah@ic.sunysb.edu

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
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Cardiac electrophysiology parameters like conduction velocity (CV) show significant temperature dependence, with Q10 values varying by diastolic interval. Understanding these thermal effects is crucial for interpreting experimental data and understanding arrhythmias.

Area of Science:

  • Cardiovascular Physiology
  • Biophysics

Background:

  • Cardiac electrophysiology studies often use sub-physiological temperatures.
  • The Arrhenius model (Q10) is commonly used for temperature extrapolation.
  • Temperature's impact on cardiac excitation dynamics requires precise quantification.

Purpose of the Study:

  • To quantify temperature dependence of cardiac excitation parameters.
  • To investigate temperature effects on restitution dynamics.
  • To provide data for reconciling experimental conditions and understanding thermal influences on arrhythmias.

Main Methods:

  • Fast fluorescence imaging in neonatal rat cardiomyocyte sheets.
  • Utilized voltage- and calcium-sensitive dyes.
  • Quantified conduction velocity (CV), calcium transient duration (CTD), action potential duration (APD), and wavelength (W) across temperatures.

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Main Results:

  • CV showed a strong temperature increase (Q10=2.3).
  • CTD and APD had smaller temperature sensitivities (Q10=1.33, 1.24).
  • Wavelength exhibited intermediate temperature sensitivity (Q10=2.05, 1.78), influenced by opposing CV and duration changes. Q10 varied with diastolic interval.

Conclusions:

  • Cardiac electrophysiology parameters exhibit distinct temperature dependencies.
  • Q10 values are not constant and vary with physiological conditions like diastolic interval.
  • Results aid in interpreting temperature-dependent data and understanding thermal effects on cardiac arrhythmias.