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In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Modeling blood flow in the gastrointestinal system.
T D S Mabotuwana1, L K Cheng, N P Smith
1Bioeng. Inst., Auckland Univ, New Zealand. t.mabotuwana@auckland.ac.nz
This study models the human mesenteric arterial system to understand intestinal blood flow. The findings provide a foundation for simulating normal and compromised blood flow in the gastrointestinal system.
Area of Science:
- Biomedical Engineering
- Cardiovascular Physiology
- Gastrointestinal Physiology
Background:
- Gastrointestinal ischemia is less understood than cardiac ischemia.
- Accurate modeling of mesenteric arterial blood flow is needed.
Purpose of the Study:
- To develop an anatomically and biophysically based model of the human mesenteric arterial system.
- To simulate normal and compromised blood flow in the intestine.
Main Methods:
- Utilized data from the Visible Human project to construct the mesenteric arterial tree model.
- Applied equations for blood flow in extensible vessels.
- Analyzed results across four cardiac contraction phases.
Main Results:
- Solved for pressure, radius, and velocity within the mesenteric arterial network.
- Presented profiles of temporally varying pressure and velocity.
- Simulated blood flow with input pressure ranging from 77 to 110 mmHg at the abdominal aorta.
Conclusions:
- This work represents a first step towards detailed simulation of intestinal blood flow.
- The model can be used to study normal and compromised mesenteric blood flow.
- Further research can build upon this model for clinical applications.
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