Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bayesian dynamic multivariate models for inferring gene interaction networks.

Yulan Liang1, Arpad Kelemen

  • 1Dept. of Biostat., State Univ. of New York, Buffalo, NY 14214, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An Integrated Immunometabolic Signature Predicts Prognosis and Immunotherapy Response in ccRCC and Identifies <i>UCN</i>-Mediated Immune Evasion as a Therapeutic Vulnerability: Evidence from In Vitro and In Vivo Studies.

Cancers·2026
Same author

Telehealth interventions for alcohol use disorder: A systematic review.

Liver research (Beijing, China)·2025
Same author

Event-triggered affine formation of second-order multi-agent systems via complex-valued Laplacian.

ISA transactions·2024
Same author

Unraveling the Degradation and Air-Induced Healing Mechanisms of Halide Perovskites under Proton Irradiation.

ACS applied materials & interfaces·2024
Same author

Use of Smartphone Apps for Improving Physical Function Capacity in Cardiac Patient Rehabilitation: Systematic Review.

JMIRx med·2023
Same author

A Physical Activity Mobile Game for Hematopoietic Stem Cell Transplant Patients: App Design, Development, and Evaluation.

JMIRx med·2023
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

This study introduces Bayesian dynamic multivariate models to analyze complex gene and protein networks, capturing temporal changes crucial for understanding genomic data in disease and treatment contexts.

Area of Science:

  • Genomics
  • Systems Biology
  • Computational Biology

Background:

  • Inferring dynamic gene and protein networks is vital in genomic research.
  • Estimating temporal correlations and non-stationarity are key challenges.

Purpose of the Study:

  • To develop Bayesian dynamic multivariate models for inferring gene network profiles.
  • To address challenges in estimating temporal correlations and non-stationarity in genomic data.

Main Methods:

  • Utilized Bayesian dynamic multivariate models with time-variant transition and observation matrices.
  • Incorporated temporal correlation structures in covariance matrix estimations.
  • Treated unevenly spaced time courses and unseen time points as hidden state variables.
  • Employed Bayesian approaches with MCMC algorithms for parameter estimation.

Related Experiment Videos

Main Results:

  • Applied models to polygenetic Affymetrix data from multiple tissues.
  • Preliminary results indicate successful capture of genomic dynamic behavior.
  • Demonstrated the model's capability in handling complex temporal dependencies.

Conclusions:

  • The proposed Bayesian dynamic multivariate models effectively capture genomic dynamic behavior.
  • These models offer a robust framework for analyzing gene and protein networks.
  • The approach holds promise for advancing genomic research in disease and treatment studies.