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Related Experiment Video

Updated: Jul 10, 2026

3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

Towards a biomechanical-based method for assessing myocardial tissue viability.

Cristian A Linte1, Marcin Wierzbicki, Usaf Aladl

  • 1Biomed. Eng., Univ. of Western Ontario, London, ON, Canada.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
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This study introduces a novel 3D biomechanical method to assess myocardial viability by quantifying contraction forces. This technique aids in diagnosing myocardial infarction (MI) by identifying regions of low contractility.

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Imaging
  • Computational Mechanics

Background:

  • Myocardial infarction (MI) diagnosis requires accurate assessment of myocardial tissue viability.
  • Current methods may not fully capture regional mechanical function.
  • Quantifying myocardial contraction forces offers a potential new diagnostic avenue.

Purpose of the Study:

  • To develop and implement a novel 3D biomechanical method for assessing myocardial viability.
  • To quantify myocardial contraction forces in response to electrophysiological stimuli.
  • To apply this method for improved myocardial infarction (MI) diagnosis.

Main Methods:

  • A 3D finite element (FE) formulation for a contraction force reconstruction algorithm was developed.

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Related Experiment Videos

Last Updated: Jul 10, 2026

3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
08:13

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes
08:19

In Vitro Assessment of Cardiac Function Using Skinned Cardiomyocytes

Published on: June 22, 2020

  • The algorithm utilizes an inverse problem solution based on linear elasticity.
  • Patient-specific cardiac models were created from high-resolution MRI data, incorporating motion information from nonrigid registration.

    • Main Results:

    • The developed algorithm was implemented and applied to clinical data.
    • A display-map of contraction force distribution was generated, superimposed on anatomical ventricle models.
    • The results enable clinicians to identify regions with reduced myocardial contractility.

    Conclusions:

    • This work presents a novel 3D biomechanical approach for myocardial viability assessment.
    • The method quantifies regional myocardial contraction forces, aiding in MI diagnosis.
    • The technique allows for visualization of impaired contractility, supporting clinical decision-making.