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Updated: Jul 10, 2026

The Olfactory System as a Model to Study Axonal Growth Patterns and Morphology In Vivo
Published on: October 30, 2014
Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension"
Nader Sanai1, Mitchel S Berger, Jose Manuel Garcia-Verdugo
1Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, Room M779, San Francisco, CA 94143-0112, USA. sanain@neurosurg.ucsf.edu
Abstract:
Curtis et al. (Research Articles, 2 March 2007, p. 1243) claimed discovery of a human neuronal migratory stream to the olfactory bulb along a putative lateral ventricular extension. However, high levels of proliferation reported with proliferating cell nuclear antigen were not confirmed using different markers, neuronal chain migration was not demonstrated, and no serial reconstruction shows a true ventricular extension.
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