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Updated: Jul 10, 2026

Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
Published on: February 28, 2013
Thymosin beta 4 induces hair growth via stem cell migration and differentiation
Deborah Philp1, Sharleen St-Surin, Hee-Jae Cha
1Cell Biology Section, NIH, NIDCR, Building 30, Room 433, 30 Convent Dr. MSC 4370, Bethesda, MD 20892, USA.
Abstract:
Thymosin beta 4 is a small 43-amino-acid molecule that has multiple biological activities, including promotion of cell migration angiogenesis, cell survival, protease production, and wound healing. We have found that thymosin beta 4 promotes hair growth in various rat and mice models including a transgenic thymosin beta 4 overexpressing mouse. We have also determined the mechanism by which thymosin beta 4 acts to promote hair growth by examining its effects on follicle stem cell growth, migration, differentiation, and protease production.
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