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Asthma I: Introduction

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...

Allergic Reactions

Allergic Reactions

Asthma: Pathogenesis and Management

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.

Asthma-IV: Diagnostic and Management

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

Asthma-I: Introduction

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:

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Related Experiment Video

Updated: Jul 10, 2026

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Understanding allergic asthma from allergen inhalation tests.

Donald W Cockcroft¹, Fredrick E Hargreave, Paul M O'Byrne

¹University of Saskatchewan, Saskatoon, Canada. don.cockcroft@usask.ca

Canadian Respiratory Journal

|October 20, 2007

Summary

The allergen challenge has advanced from diagnosing allergen-induced diseases to studying asthma pathophysiology and treatment. This research confirms immunoglobulin E

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Last Updated: Jul 10, 2026

Murine Model of Allergen Induced Asthma

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Published on: May 14, 2012

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

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Area of Science:

Allergy and Immunology
Respiratory Medicine
Pharmacology

Background:

The allergen challenge has evolved significantly over 150 years.
Initially used to identify causes of allergen-induced diseases, it is now a precise tool for asthma research.

Observation:

The authors' work highlights key aspects of allergen challenge studies.
Contributions include confirming immunoglobulin E (IgE) dependence in late asthmatic responses.

Findings:

Airway hyper-responsiveness is crucial in determining allergen response.
Allergen exposure increases airway hyper-responsiveness and can involve eosinophilic inflammation.
Beta(2)-agonist use may alter airway response to allergens.

Implications:

Understanding allergen-induced airway responses advances asthma pathophysiology knowledge.
The allergen challenge is vital for developing and testing new asthma therapies.
Multicenter trials utilize allergen challenges to explore novel therapeutic strategies for asthma.