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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Diterpenoids from the roots of Croton oblongifolius
Witoon Youngsa-ad1, Nattaya Ngamrojanavanich, Chulabhorn Mahidol
1Chulabhorn Research Institute, Vipavadee-Rangsit Highway, Bangkok, Thailand.
Abstract:
Two new clerodane diterpenes, methyl 15,16-epoxy-3,13(16),14- ENT-clerodatrien-18,19-olide-17-carboxylate ( 1) and dimethyl 15,16-epoxy-12-oxo-3,13(16),14- ENT-clerodatriene-17,18-dicarboxylate ( 2), together with seven known compounds ( 3 - 9), were isolated from the roots of Croton oblongifolius. The isolated compounds showed only mild cytotoxic activity against HuCCA-1, KB, HeLa, MDA-MB231, and T47D cell lines with IC (50) values ranging from 10 to 50 microg/mL.
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