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Updated: Jul 10, 2026
Computational Analysis of the Caenorhabditis elegans Germline to Study the Distribution of Nuclei, Proteins, and the Cytoskeleton
Published on: April 19, 2018
Caenorhabditis elegans germ line: a model for stem cell biology
1New York University School of Medicine, Developmental Genetics, Skirball Institute for Biomolecular Medicine, Department of Pathology, Helen and Martin Kimmel Center for Stem Cell Biology, New York, New York 10016, USA. jhubbard@saturn.med.nyu.edu
Abstract:
Like many stem cell systems, the Caenorhabditis elegans germ line contains a self-renewing germ cell population that is maintained by a niche. Although the exact cellular mechanism for self-renewal is not yet known, three recent studies shed considerable light on the cell cycle behavior of germ cells, including a support for significant and plastic renewal potential. This review brings together the results of the three recent cell-based studies, places them in the context of previous work, and discusses future perspectives for the field.
