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Related Experiment Video

Updated: Jul 10, 2026

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging
07:28

Thinned-skull Cortical Window Technique for In Vivo Optical Coherence Tomography Imaging

Published on: November 19, 2012

Optical diagnostic techniques in the head and neck.

Tahwinder Upile1, Waseem Jerjes, Christian S Betz

  • 1Royal National ENT Hospital.

Dental Update
|October 24, 2007
PubMed
Summary

This review compares microendoscopy, fluorescence spectroscopy (FS), and elastic scattering spectroscopy (ESS) against traditional histopathology. These advanced techniques show promise as adjuncts or alternatives for defining tissue involvement in surgical specimens.

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Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation
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Optical Frequency Domain Imaging of Ex vivo Pulmonary Resection Specimens: Obtaining One to One Image to Histopathology Correlation

Published on: January 22, 2013

Area of Science:

  • Medical imaging and diagnostics
  • Optical spectroscopy in medicine

Background:

  • Histopathology is the gold standard for defining tissue involvement.
  • There is a need for advanced diagnostic tools to complement or replace traditional methods.

Purpose of the Study:

  • To compare microendoscopy, fluorescence spectroscopy (FS), and elastic scattering spectroscopy (ESS) with histopathology.
  • To assess the utility of these techniques in defining tissue involvement in surgical specimens.

Main Methods:

  • Review of recent prospective studies.
  • Comparison of optical techniques (microendoscopy, FS, ESS) with histopathology.
  • Analysis of formalin-fixed surgical specimens.

Main Results:

  • Optical techniques show potential for defining tissue involvement.
  • These methods may serve as adjuncts or alternatives to histopathology.
  • Specific findings from comparative studies are detailed.

Conclusions:

  • Microendoscopy, FS, and ESS are non-invasive diagnostic aids.
  • These techniques can guide accurate treatment delivery, such as photodynamic therapy.
  • They offer improved precision in targeting abnormal tissue areas.