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Updated: Jul 10, 2026

Real-time Observation of the DNA Strand Exchange Reaction Mediated by Rad51
Published on: February 13, 2019
The dynamics of intermittent strand separation in double-stranded DNA
Debarati Chatterjee1, Srabanti Chaudhury, Binny J Cherayil
1Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560012, India.
Abstract:
The transient rupture and reformation of hydrogen bonds between base pairs on distinct chains of double-stranded DNA ("bubble" dynamics) is modeled in terms of the fluctuating distance between the bases. The fluctuations in the distance are assumed to be governed by a simple Langevin equation with a quadratic potential under conditions of high friction. A critical distance of separation L must be achieved before a bubble defect is considered to have been formed. The decay of the dynamic correlations between states of the DNA that have such defects and those that do not has been calculated from the above model and has been found to reproduce the trends in experimental measurements of the same quantity.
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