Related Experiment Video
Updated: Jul 10, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Canine candidate genes for dilated cardiomyopathy: annotation of and polymorphic markers for 14 genes
Anje C Wiersma1, Peter Aj Leegwater, Bernard A van Oost
1Small Animal Teaching Hospital, University of Liverpool, Leahurst, Chester High Road, Neston, CH64 7TE, UK. a.c.wiersma@uu.nl
Background:
Dilated cardiomyopathy is a myocardial disease occurring in humans and domestic animals and is characterized by dilatation of the left ventricle, reduced systolic function and increased sphericity of the left ventricle. Dilated cardiomyopathy has been observed in several, mostly large and giant, dog breeds, such as the Dobermann and the Great Dane. A number of genes have been identified, which are associated with dilated cardiomyopathy in the human, mouse and hamster. These genes mainly encode structural proteins of the cardiac myocyte.
Results:
We present the annotation of, and marker development for, 14 of these genes of the dog genome, i.e. alpha-cardiac actin, caveolin 1, cysteine-rich protein 3, desmin, lamin A/C, LIM-domain binding factor 3, myosin heavy polypeptide 7, phospholamban, sarcoglycan delta, titin cap, alpha-tropomyosin, troponin I, troponin T and vinculin. A total of 33 Single Nucleotide Polymorphisms were identified for these canine genes and 11 polymorphic microsatellite repeats were developed.
Conclusion:
The presented polymorphisms provide a tool to investigate the role of the corresponding genes in canine Dilated Cardiomyopathy by linkage analysis or association studies.
Related Concept Videos
Cardiomyopathy II: Dilated Cardiomyopathy
Incomplete Dominance
Single Nucleotide Polymorphisms-SNPs
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
