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Cerebrospinal fluid ascorbic acid levels during the neonatal period
1N.I.C.U., Department of Pediatrics, Hadassah University Hospital, Mt. Scopus, Jerusalem, Israel.
Summary
Newborn infants have varying cerebrospinal fluid (CSF) ascorbic acid levels, with preterm infants initially showing higher levels. This study suggests active transport of ascorbic acid into the brain and potential benefits of supplementation in neurological disorders.
Area of Science:
- Neonatal Medicine
- Neuroscience
- Biochemistry
Background:
- Ascorbic acid (vitamin C) plays a crucial role in neurological function.
- Understanding ascorbic acid transport in newborns is vital for assessing brain health.
Purpose of the Study:
- To determine plasma and cerebrospinal fluid (CSF) ascorbic acid levels in term and preterm neonates.
- To investigate the relationship between plasma and CSF ascorbic acid levels.
- To explore potential differences in ascorbic acid levels in neonates with neurological disorders.
Main Methods:
- Measurement of plasma and CSF ascorbic acid levels in 13 term and 17 preterm infants.
- Analysis of CSF/plasma ascorbic acid ratios.
- Comparison of levels between healthy neonates and those with neurological conditions.
Main Results:
- Preterm infants had higher initial CSF ascorbate levels compared to term infants.
- CSF and plasma ascorbate levels correlated negatively, suggesting saturable active transport.
- Neonate with neurological disorders exhibited lower CSF/plasma ascorbate ratios than healthy infants.
Conclusions:
- Evidence suggests an active, saturable transport mechanism for ascorbic acid into the central nervous system.
- Lower CSF ascorbic acid levels in neurologically impaired neonates warrant further investigation.
- Ascorbic acid administration may be beneficial for neonates experiencing neurological insults.