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Updated: Jul 10, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Evaluating the evidence for assessing BNP and NT-proBNP levels
J W Busse1, D Bassler, G H Guyatt
1Department of Clinical Epidemiology and Biostatistics, McMaster University Faculty of Health Sciences, Hamilton, ON, Canada.
Objectives:
To provide an overview of 5 systematic reviews in this issue of Clinical Biochemistry addressing the diagnostic and prognostic power of natriuretic peptides.
Design And Methods:
Editorial.
Results:
Limited quality of the primary studies and the large variability in their results limit the inferences that can be drawn from reviews in this series.
Conclusions:
The current data justify neither enthusiastic use, nor confident rejection, of BNP and NT-proBNP levels to inform the prognosis or diagnosis of heart failure.
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