Discovery of recurrent multiple brain states in non-convulsive status epilepticus
Michel J A M van Putten1, Maurice H P M van Putten
1Department of Neurology and Clinical Neurophysiology, Medisch Spectrum Twente, 7500 KA, Enschede, The Netherlands. m.vanputten@mailcss.com
Objective:
We study burst-like patterns of epileptiform discharges in non-convulsive status epilepticus (SE).
Methods:
Epileptiform burst-like transients were identified by estimating the amplitude envelope of the EEG signal, and recurrence and similarities were identified by pairwise matching in the time-domain.
Results:
We identified similarities in the onset of a significant fraction of the epileptiform bursts, and a bimodal distribution of the burst durations.
Conclusions:
Bursts of epileptiform discharges during a non-convulsive SE are manifestations of multiple patterns of recurring brain states.
Significance:
Quantitative description of ictal phenomena in epilepsy and status epilepticus adds to the knowledge of abnormal brain behavior and may assist in improved patient care.
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