Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The nucleus: a black box being opened.

R van Driel1, B Humbel, L de Jong

  • 1E.C. Slater Institute for Biochemical Research, University of Amsterdam, The Netherlands.

Journal of Cellular Biochemistry
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI-driven target definition using CE-T1w and black blood sequence imaging in stereotactic radiosurgery for brain metastases.

European journal of radiology·2026
Same author

The Femoral Neck System versus the Dynamic Hip Screw in patients with a femoral neck fracture: 2-year follow-up of a multicenter study.

Injury·2025
Same author

A prospective randomized double-blind trial of the efficacy of a bilateral lumbar erector spinae block on the 24h morphine consumption after posterior lumbar inter-body fusion surgery.

Trials·2019
Same author

Learning from Parkinson's patients: Usability of the Cyclops dry powder inhaler.

International journal of pharmaceutics·2019
Same author

Comparison between postmortem computed tomography and autopsy in the detection of traumatic head injuries.

Journal of neuroradiology = Journal de neuroradiologie·2019
Same author

Needs and preferences of informal caregivers regarding outpatient care for the elderly: a systematic literature review.

BMC geriatrics·2019
Same journal

Zinc Finger Proteins as Regulators of Organ Fibrosis.

Journal of cellular biochemistry·2026
Same journal

Intrinsic Disorder Status in Human Proteins Interacting With SARS-CoV-2 Proteins: Insights From Five Years of Translational Research.

Journal of cellular biochemistry·2026
Same journal

The Effect of Protein Tagging on Aggregation and Phase Separation.

Journal of cellular biochemistry·2026
Same journal

TRIM32 Alleviates the Inflammation in Spinal Cord Injury Progression Through Inducing the Ubiquitination Degradation of TLR4.

Journal of cellular biochemistry·2026
Same journal

Bedaquiline Binding at the Leading Site of Mycobacterium tuberculosis ATP Synthase Induces Distinct Structural and Dynamic Changes.

Journal of cellular biochemistry·2026
Same journal

Agrin Ablation in Osteoblasts Compromises Long Bone Structure and Osteoblastic Differentiation of Mesenchymal Stem Cells.

Journal of cellular biochemistry·2026
See all related articles

Recent advances reveal the cell nucleus is highly organized. Nuclear functions and chromatin loops are localized to the nuclear matrix, impacting gene expression regulation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Limited understanding of cell nucleus structure and function historically.
  • Emerging insights from ultrastructural analysis and nuclear matrix research.

Purpose of the Study:

  • To elucidate the structural and functional organization of the cell nucleus.
  • To understand the role of the nuclear matrix in nuclear organization.

Main Methods:

  • Ultrastructural analysis.
  • Investigation of nuclear matrix properties.

Main Results:

  • Nuclear functions (replication, transcription, RNA processing, transport) are localized and associated with the nuclear matrix.
  • Chromatin is organized into discrete loops, demarcated by nuclear matrix attachment regions (MARs).

Related Experiment Videos

  • Each chromatin loop may contain one or more genes.

    • Conclusions:

    • The nuclear matrix plays a crucial role in organizing nuclear functions and chromatin.
    • Chromatin loop organization has significant implications for gene expression regulation.