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Published on: July 31, 2017
Preconditioning with oxygen attenuates rat renal ischemia-reperfusion injury
Bahram Rasoulian1, Hassan Mohammadhosseniakbari, Mehri Kadkhodaee
1Research Center for Trauma, Baqiyatallah University of Medical Sciences, Tehran, Iran. rasoulian@irimc.org
Background:
Short time pretreatment with oxygen is reported to be protective against subsequent ischemia-reperfusion (IR) injury of heart and spinal cord in some animal models. The purpose of this study was to investigate the effects of pre-exposure to hyperoxic environment on rat renal IR injury for the first time.
Materials And Methods:
The effects of 1 h/d pretreatment with oxygen (>or=95%) for 5 days on a right nephrectomized rat model of renal IR injury was investigated by comparing creatinine clearance, fractional excretion of sodium, plasma creatinine, blood urea nitrogen, and histological injury scores among three groups: IR (40 min ischemia-24 h reperfusion), sham (no IR), and hyperoxia (5 days intermittent pretreatment with oxygen + IR).
Results:
Intermittent pretreatment with oxygen resulted in significant improvement of creatine clearance and fractional excretion of sodium (P
Conclusions:
The present findings demonstrate that intermittent pre-exposure to hyperoxic environment can reduce subsequent renal IR injury.
