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Right ventricular function following cardiac resynchronization therapy.

Navin Rajagopalan1, Matthew S Suffoletto, Masaki Tanabe

  • 1Cardiovascular Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The American Journal of Cardiology
|October 24, 2007
PubMed
Summary
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Cardiac resynchronization therapy (CRT) significantly improves right ventricular (RV) function, measured by RV S(m). This therapy benefits RV function independently of left ventricular ejection fraction improvements.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Echocardiography

Background:

  • Right ventricular (RV) function changes after cardiac resynchronization therapy (CRT) are not well understood.
  • Assessing RV function is crucial for heart failure management.

Purpose of the Study:

  • To evaluate the impact of CRT on RV function using tissue Doppler imaging.
  • To quantify changes in global RV systolic function post-CRT.

Main Methods:

  • Tissue Doppler imaging was used to measure RV systolic velocity (RV S(m)) in 35 heart failure patients before and after CRT.
  • Left ventricular ejection fraction was assessed using biplane Simpson's method.

Main Results:

  • RV S(m) significantly improved after CRT (5.4 to 7.1 cm/s, p <0.001).

Related Experiment Videos

  • Left ventricular ejection fraction also significantly improved (26% to 34%, p <0.001).
  • Improved RV function was observed in 60% of patients and was independent of LV function or dyssynchrony.

    • Conclusions:

    • CRT leads to significant improvements in RV function.
    • The beneficial effects of CRT on RV function are independent of improvements in left ventricular ejection fraction.