Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer molecular pattern discovery by subspace consensus kernel classification.

Xiaoxu Han1

  • 1Department of Mathematics and Bioinformatics Program, Eastern Michigan University, Ypsilanti, MI 48197, USA. xiaoxu.han@emich.edu

Computational Systems Bioinformatics. Computational Systems Bioinformatics Conference
|October 24, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evolutionary tuning of a biosynthetic gene cluster drives furanocoumarin accumulation and diversification.

Nature communications·2026
Same author

From Surgical Salvage to Blindness Prevention: A Real-World Study of Intraocular Surgery in Monocular Patients.

Journal of clinical medicine·2026
Same author

Transmitted and pretreatment drug resistance among 69 HIV-1 CRFs in China: the first systematic analysis.

Emerging microbes & infections·2026
Same author

Dysregulated Polarized Secretion of Small Extracellular Vesicles in the Retinal Pigment Epithelium: Mechanisms and Pathological Roles in Age-Related Macular Degeneration.

Journal of inflammation research·2026
Same author

Reply to comment on SARS-CoV-2 variant-specific humoral immunity and long-term immune recovery in people living with HIV in the ancestral vaccine era.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases·2026
Same author

Independent Degeneration of Photoreceptors and Retinal Pigment Epithelium: Multimodal Imaging Evidence From Choroideremia Carriers.

Investigative ophthalmology & visual science·2026

This study introduces a novel subspace consensus kernel clustering algorithm for discovering cancer molecular patterns. The method enhances classification accuracy in gene expression data, outperforming existing techniques.

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Machine Learning in Oncology

Background:

  • Discovering cancer molecular patterns is crucial for molecular diagnostics.
  • Gene/protein expression data present challenges for traditional unsupervised classification algorithms.

Purpose of the Study:

  • To develop an efficient algorithm for cancer molecular pattern discovery.
  • To improve classification accuracy for gene and protein expression data.

Main Methods:

  • Developed a subspace consensus kernel clustering algorithm based on projected gradient nonnegative matrix factorization (PG-NMF).
  • Integrated convergence-soundness parts-based learning, subspace, and kernel space clustering.
  • Applied a framework involving input space, subspace, and kernel space clustering.

Related Experiment Videos

Main Results:

  • Demonstrated more effective classification results compared to classic NMF, sparse-NMF, KNN, and SVM on four benchmark cancer datasets.
  • The algorithm achieves superior performance in classifying microarray and proteomics data.

Conclusions:

  • The proposed algorithm offers a robust approach for cancer molecular pattern discovery.
  • It can generate a family of classification algorithms by varying subspace transforms and kernel clustering methods.