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Related Experiment Video

Updated: Jul 10, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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DeltaNp73alpha regulates MDR1 expression by inhibiting p53 function.

A Vilgelm1, J X Wei, M B Piazuelo

  • 1Department of Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.

Oncogene
|October 24, 2007
PubMed
Summary
This summary is machine-generated.

The DeltaNp73alpha protein, upregulated in gastric cancer, enhances drug resistance by increasing MDR1 mRNA and p-glycoprotein. This interaction with p53 at the MDR1 promoter may drive oncogenesis and affect chemotherapy response.

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Yeast As a Chassis for Developing Functional Assays to Study Human P53
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Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Last Updated: Jul 10, 2026

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Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

Area of Science:

  • Molecular oncology
  • Cancer biology
  • Biochemistry

Background:

  • p73 is a transcription factor and member of the p53 protein family.
  • DeltaNp73alpha is an N-terminally truncated isoform of p73.
  • DeltaNp73 is upregulated in human gastric carcinoma, suggesting an oncogenic role.

Purpose of the Study:

  • To explore the mechanism by which DeltaNp73alpha contributes to chemotherapeutic drug response.
  • To investigate the role of DeltaNp73alpha in gastric cancer drug resistance.

Main Methods:

  • Analysis of DeltaNp73alpha expression in gastric carcinoma.
  • Investigating the effect of DeltaNp73alpha on MDR1 mRNA and p-glycoprotein (p-gp) expression.
  • Assessing p-gp functional activity in gastric cancer cells.
  • Examining the interaction between DeltaNp73alpha and p53 at the MDR1 promoter.

Main Results:

  • DeltaNp73alpha is upregulated in human gastric carcinoma.
  • DeltaNp73alpha upregulates MDR1 mRNA and p-glycoprotein (p-gp).
  • Increased p-gp functional activity was observed in gastric cancer cells.
  • DeltaNp73alpha interacts with p53 at the MDR1 promoter to upregulate MDR1.

Conclusions:

  • DeltaNp73alpha plays an oncogenic role in gastric cancer by upregulating MDR1 and p-gp.
  • This upregulation contributes to chemotherapeutic drug resistance.
  • The interaction between DeltaNp73alpha and p53 at the MDR1 promoter is a key mechanism driving these effects.