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Updated: Jul 10, 2026
09:54
A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
Optimized hyperventilation preserves 2,3-diphosphoglycerate in severe traumatic brain injury
Rayne Borges Torres1, Renato Giuseppe Giovanni Terzi, Antônio Luís Eiras Falcão
1Campinas State University, Campinas, São Paulo, Brazil. raynebt@yahoo.com.br
Arquivos De Neuro-Psiquiatria
|October 24, 2007
Summary
In severe traumatic brain injury (TBI) patients, the expected rise in 2,3-diphosphoglycerate (2,3-DPG) with hyperventilation was not observed. This may be due to intermittent ventilation protocols used in TBI management.
Area of Science:
- Neuroscience
- Physiology
- Critical Care Medicine
Background:
- 2,3-diphosphoglycerate (2,3-DPG) concentration physiologically increases with elevated pH and hyperventilation.
- This response is relevant in managing patients with severe traumatic brain injury (TBI).
Purpose of the Study:
- To investigate the physiological response of 2,3-DPG concentration to hyperventilation in severe TBI patients.
- To determine if optimized hyperventilation protocols affect 2,3-DPG levels in TBI.
Main Methods:
- Daily measurement of 2,3-DPG concentration over six days in eleven severe TBI patients.
- Patients required optimized hyperventilation due to intracranial hypertension.
Main Results:
- A correlation was found between blood pH and 2,3-DPG concentration.
- 2,3-DPG levels remained largely within normal limits, with a minor increase on day six.
- 2,3-DPG concentration significantly correlated with the partial pressure of oxygen (P50st).
Conclusions:
- The anticipated increase in 2,3-DPG concentration with hyperventilation was not observed in severe TBI patients.
- This lack of response might be attributed to the intermittent nature of the ventilation protocol, rather than sustained hyperventilation.
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